Peritransplant Cardiometabolic and Mitochondrial Function: The Missing Piece in Donor Heart Dysfunction and Graft Failure

Primary graft dysfunction is an important cause of morbidity and mortality after cardiac transplantation. Donor brain stem death (BSD) a significant contributor to donor heart primary dysfunction. There remain substantial gaps in the mechanistic understanding peritransplant One these metabolism metabolic function. The healthy “omnivore,” capable utilizing multiple sources nutrients fuel its enormous energetic demand. When this fails, inflexibility leads myocardial Data have hinted at disturbance BSD subsequent transplantation; however, there limited evidence demonstrating specific or mitochondrial This review will examine literature surrounding cardiometabolic function donor, organ preservation, A more comprehensive subject may then help identify cardioprotective strategies improve number quality hearts.